Structure determination of acylated proteins.

In conclusion, our results show that inhibitors of acylation may be developed on the basis of analogues of myristic acid. Such inhibitors inhibit not only the N-myristoyl transferase activity, but also acylation of proteins in intact cells. They are also able to inhibit virus acylation. Preliminary results show that they inhibit HIV release from infected H9 cells in culture and therefore may be potential antiviral agents. A rather surprising result is that glucosamine may also interfere with acylation of viral proteins.